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The Pretty Little Peptides — sunset beach brand badgeKayethel Peptides
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Comparison Analysis

Semaglutide vs Retatrutide

Single GLP-1R agonist versus the first triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously.

Criterion
Receptor TargetsGLP-1R onlyGLP-1R + GIPR + GCGR (triple agonist)
Molecular Weight4113.58 g/mol~5600 g/mol
MechanismcAMP/PKA via GLP-1RTriple incretin + glucagon thermogenesis
Unique FeatureGold-standard GLP-1R selectivityGCGR adds hepatic lipid oxidation
Research MaturityExtensively characterizedEmerging, novel class
Price (5 mg)$69.00$129.00

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Research Assessment

Semaglutide remains the reference compound for GLP-1R-specific research. Retatrutide is for investigating the additive effects of glucagon receptor activation on thermogenesis and hepatic lipid metabolism beyond dual agonism.

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⬤ For laboratory research use only. Not for human consumption.