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⬤ All products are sold strictly as laboratory reagents for in-vitro research use only. Not for human or veterinary use.
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Comparison Analysis

CJC-1295 vs IGF-1 LR3

An upstream versus downstream comparison in the GH/IGF-1 axis. CJC-1295 stimulates endogenous GH release via GHRH receptor, while IGF-1 LR3 directly activates IGF-1 receptor signaling.

Criterion
Axis PositionUpstream (GHRH analog)Downstream (IGF-1 analog)
ReceptorGHRH-R on pituitaryIGF-1R (PI3K/Akt, MAPK)
MechanismStimulates pulsatile GH releaseDirect receptor agonism, mTOR activation
Half-life ModDAC → albumin binding (~8 days)Arg3 + N-terminal extension (reduced IGFBP)
FeedbackPreserves physiological feedbackBypasses GH axis feedback
Price (2 mg)$38.00$89.00 (1 mg)

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Research Assessment

CJC-1295 is the choice for studying physiological GH axis modulation with preserved feedback. IGF-1 LR3 is for direct receptor-level studies where bypassing the GH axis is desirable. They represent complementary tools for different levels of the same signaling cascade.

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