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Growth Hormone Peptides

GHRH analogs, IGF-1 variants, and mechano growth factors

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Overview

Growth hormone peptides operate at multiple levels of the GH/IGF-1 axis: upstream GHRH receptor agonism for pulsatile GH release, downstream IGF-1 receptor activation for direct signaling, and local mechano growth factor pathways for tissue-specific responses.

How These Mechanisms Work

CJC-1295 stimulates pituitary somatotrophs via GHRH-R, preserving physiological feedback. IGF-1 LR3 directly activates IGF-1R with reduced IGFBP binding for prolonged receptor engagement. MGF and PEG-MGF activate satellite cells through autocrine/paracrine signaling distinct from systemic IGF-1.

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