Quick Answer
GLP-1 (Glucagon-Like Peptide-1) is an incretin hormone that activates the GLP-1 receptor, modulating insulin secretion, appetite, and gastric motility.
GLP-1 is a 30-amino acid peptide hormone produced by intestinal L-cells in response to nutrient intake. It activates the GLP-1 receptor (GLP-1R), a class B G-protein coupled receptor expressed on pancreatic beta cells, hypothalamic neurons, and GI tract cells. GLP-1R activation triggers the Gs → cAMP → PKA signaling cascade, enhancing glucose-dependent insulin secretion, suppressing glucagon release, and delaying gastric emptying. Native GLP-1 has a half-life of only 2–3 minutes due to DPP-4 enzymatic degradation. Research analogs like semaglutide use structural modifications (Aib substitution, fatty acid acylation) to resist degradation and extend half-life to ~7 days.
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BPC-157 is a synthetic 15-amino acid peptide fragment derived from human gastric juice protein, studied for tissue repair via VEGF upregulation and nitric oxide modulation.
What is Semaglutide?Semaglutide is a long-acting GLP-1 receptor agonist with 94% homology to native GLP-1, modified for extended half-life via albumin binding.
How do peptides work?Peptides are short chains of amino acids that bind specific receptors to trigger intracellular signaling cascades, modulating biological processes at the molecular level.
What is Tirzepatide?Tirzepatide is a dual GIP/GLP-1 receptor agonist — the first compound to simultaneously target both incretin receptors for synergistic metabolic research.
How should research peptides be stored?Lyophilized peptides should be stored at -20°C. Reconstituted peptides should be stored at 2–8°C and used within the specified stability window.
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